cdk1 protein domain prediction Search Results


cdk1 protein domain prediction  (InterPro Inc)
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InterPro Inc cdk1 protein domain prediction
In normal two‐cell mouse embryos, LincGET works as a transcription factor, mediating the cis‐regulatory activity of GLKLTRs, and an inhibitor of exon skipping, partially through decreasing hnRNP U, FUBP1, and ILF2 protein levels (up). However, when LincGET is depleted, disordered transcription and disordered RNA splicing would result in disordered ZGA, MAPK signaling inhibition, and exon skipping of some M‐phase‐associated genes, including <t>Cdk1,</t> leading to G2/M block (down).
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In normal two‐cell mouse embryos, LincGET works as a transcription factor, mediating the cis‐regulatory activity of GLKLTRs, and an inhibitor of exon skipping, partially through decreasing hnRNP U, FUBP1, and ILF2 protein levels (up). However, when LincGET is depleted, disordered transcription and disordered RNA splicing would result in disordered ZGA, MAPK signaling inhibition, and exon skipping of some M‐phase‐associated genes, including Cdk1, leading to G2/M block (down).

Journal: EMBO Reports

Article Title: A novel long intergenic noncoding RNA indispensable for the cleavage of mouse two‐cell embryos

doi: 10.15252/embr.201642051

Figure Lengend Snippet: In normal two‐cell mouse embryos, LincGET works as a transcription factor, mediating the cis‐regulatory activity of GLKLTRs, and an inhibitor of exon skipping, partially through decreasing hnRNP U, FUBP1, and ILF2 protein levels (up). However, when LincGET is depleted, disordered transcription and disordered RNA splicing would result in disordered ZGA, MAPK signaling inhibition, and exon skipping of some M‐phase‐associated genes, including Cdk1, leading to G2/M block (down).

Article Snippet: CDK1 protein domain prediction by InterPro ( http://www.ebi.ac.uk/interpro/ ).

Techniques: Activity Assay, Inhibition, Blocking Assay